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Issue 14, 2012
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The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach

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Abstract

While the use of additives to control the crystallization of polymorphs is well known, similar methodology to promote the crystallization of a metastable conglomerate over a stable racemic compound in enantiomeric systems has not been reported. Here we demonstrate this phenomenon in the case of 2-chloromandelic acid.

Graphical abstract: The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach

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Publication details

The article was received on 04 Oct 2011, accepted on 09 Nov 2011 and first published on 09 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16173C
Chem. Commun., 2012,48, 1976-1978

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    The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach

    R. J. Davey, G. Sadiq, K. Back, L. Wilkinson and C. C. Seaton, Chem. Commun., 2012, 48, 1976
    DOI: 10.1039/C1CC16173C

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