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Issue 20, 2012
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Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

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Abstract

To perform remote and direct sampling for mass spectrometry, solid probe assisted nanoelectrospray ionization (SPA-nanoESI) has been newly developed. After capturing the sample on the tip of the needle by sticking it to the biological tissue, the needle was inserted into the solvent-preloaded nanoESI capillary from the backside. NanoESI gave abundant ion signals for human kidney tissues and the liver of a living mouse. The method is easy to operate and versatile because any biological specimen could be sampled away from the mass spectrometer. Minimal invasiveness is another merit of this method.

Graphical abstract: Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

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Supplementary files

Article information


Submitted
24 Jul 2012
Accepted
15 Aug 2012
First published
16 Aug 2012

Analyst, 2012,137, 4658-4661
Article type
Communication

Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

M. K. Mandal, K. Yoshimura, S. Saha, S. Ninomiya, Md. O. Rahman, Z. Yu, L. C. Chen, Y. Shida, S. Takeda, H. Nonami and K. Hiraoka, Analyst, 2012, 137, 4658
DOI: 10.1039/C2AN36006C

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