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Issue 20, 2012
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Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

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Abstract

To perform remote and direct sampling for mass spectrometry, solid probe assisted nanoelectrospray ionization (SPA-nanoESI) has been newly developed. After capturing the sample on the tip of the needle by sticking it to the biological tissue, the needle was inserted into the solvent-preloaded nanoESI capillary from the backside. NanoESI gave abundant ion signals for human kidney tissues and the liver of a living mouse. The method is easy to operate and versatile because any biological specimen could be sampled away from the mass spectrometer. Minimal invasiveness is another merit of this method.

Graphical abstract: Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

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Publication details

The article was received on 24 Jul 2012, accepted on 15 Aug 2012 and first published on 16 Aug 2012


Article type: Communication
DOI: 10.1039/C2AN36006C
Analyst, 2012,137, 4658-4661

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    Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

    M. K. Mandal, K. Yoshimura, S. Saha, S. Ninomiya, Md. O. Rahman, Z. Yu, L. C. Chen, Y. Shida, S. Takeda, H. Nonami and K. Hiraoka, Analyst, 2012, 137, 4658
    DOI: 10.1039/C2AN36006C

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