Jump to main content
Jump to site search

Issue 24, 2012
Previous Article Next Article

A simplified electrospray ionization source based on electrostatic field induction for mass spectrometric analysis of droplet samples

Author affiliations

Abstract

A simplified electrospray ionization source based on electrostatic field induction is introduced in this paper. The electrostatic field induced spray ionization, termed EFISI, is easily performed using a needle electrode and a capillary, and it does not require heat, gas, a syringe pump or any other equipment. A high voltage is applied to a needle electrode which does not contact the sample. The capillary is used as a sample spray emitter without any electrical contact or tip modification. As only a 1 μL sample droplet is needed for analysis with no or little pretreatment, the EFISI source is particularly suitable for the mass spectrometric analysis of microlitre volume samples. The change of charge distribution in the droplet solution, by the induction of an external electrostatic field from the needle electrode, is proposed to be the main cause of ion formation. We demonstrate its feasibility for the characterization of a wide range of organic compounds and biomolecules in pure solutions or complex matrices. The influence of sample capillary length and droplet solvent composition on the ionization process are also discussed.

Graphical abstract: A simplified electrospray ionization source based on electrostatic field induction for mass spectrometric analysis of droplet samples

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Jul 2012, accepted on 28 Sep 2012 and first published on 01 Oct 2012


Article type: Paper
DOI: 10.1039/C2AN35909J
Analyst, 2012,137, 5743-5748

  •   Request permissions

    A simplified electrospray ionization source based on electrostatic field induction for mass spectrometric analysis of droplet samples

    X. Lu, H. Chen, X. Li, J. Chen and X. Yang, Analyst, 2012, 137, 5743
    DOI: 10.1039/C2AN35909J

Search articles by author

Spotlight

Advertisements