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Issue 23, 2012
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Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells

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Abstract

Herein, we report the application of synthesized fluorescent, water soluble polymers for post-translational subtyping and differentiation of breast cancer cells in vitro. The fluorescence emission spectra from these polymers were modulated differently in the presence of conditioned cell culture media from various breast cancer cells. These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous conditions.

Graphical abstract: Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells

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Article information


Submitted
27 Jun 2012
Accepted
03 Oct 2012
First published
04 Oct 2012

Analyst, 2012,137, 5487-5490
Article type
Communication

Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells

M. D. Scott, R. Dutta, M. K. Haldar, A. Wagh, T. R. Gustad, B. Law, D. L. Friesner and S. Mallik, Analyst, 2012, 137, 5487
DOI: 10.1039/C2AN35877H

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