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Issue 19, 2012
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Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

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Abstract

Novel pH-activatable fluorescent probes with various pKa values have been developed utilizing 4-nitro-benzo[1,2,5]oxadiazole derivatives (NBD) as fluorophores and piperazine moieties as proton receptors. Under acidic conditions, probe FoPz displayed significant fluorescent enhancement of about 30 fold with a pKa value of 5.70 and it responds rapidly and sensitively to intracellular pH distributions and cellular pH fluctuations.

Graphical abstract: Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

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Publication details

The article was received on 21 May 2012, accepted on 23 Jul 2012 and first published on 24 Jul 2012


Article type: Communication
DOI: 10.1039/C2AN35671F
Analyst, 2012,137, 4418-4420

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    Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

    R. Huang, S. Yan, X. Zheng, F. Luo, M. Deng, B. Fu, Y. Xiao, X. Zhao and X. Zhou, Analyst, 2012, 137, 4418
    DOI: 10.1039/C2AN35671F

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