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Issue 13, 2012
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Using a nanopore for single molecule detection and single cell transfection

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Abstract

We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.

Graphical abstract: Using a nanopore for single molecule detection and single cell transfection

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Article information


Submitted
13 Feb 2012
Accepted
22 May 2012
First published
23 May 2012

Analyst, 2012,137, 3020-3027
Article type
Paper

Using a nanopore for single molecule detection and single cell transfection

E. M. Nelson, V. Kurz, J. Shim, W. Timp and G. Timp, Analyst, 2012, 137, 3020
DOI: 10.1039/C2AN35571J

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