Jump to main content
Jump to site search

Issue 15, 2012
Previous Article Next Article

Automated correlation and classification of secondary ion mass spectrometry images using a k-means cluster method

Author affiliations

Abstract

We present a novel method for correlating and classifying ion-specific time-of-flight secondary ion mass spectrometry (ToF-SIMS) images within a multispectral dataset by grouping images with similar pixel intensity distributions. Binary centroid images are created by employing a k-means-based custom algorithm. Centroid images are compared to grayscale SIMS images using a newly developed correlation method that assigns the SIMS images to classes that have similar spatial (rather than spectral) patterns. Image features of both large and small spatial extent are identified without the need for image pre-processing, such as normalization or fixed-range mass-binning. A subsequent classification step tracks the class assignment of SIMS images over multiple iterations of increasing n classes per iteration, providing information about groups of images that have similar chemistry. Details are discussed while presenting data acquired with ToF-SIMS on a model sample of laser-printed inks. This approach can lead to the identification of distinct ion-specific chemistries for mass spectral imaging by ToF-SIMS, as well as matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI).

Graphical abstract: Automated correlation and classification of secondary ion mass spectrometry images using a k-means cluster method

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Nov 2011, accepted on 11 Apr 2012 and first published on 08 May 2012


Article type: Paper
DOI: 10.1039/C2AN16122B
Analyst, 2012,137, 3479-3487

  •   Request permissions

    Automated correlation and classification of secondary ion mass spectrometry images using a k-means cluster method

    A. R. Konicek, J. Lefman and C. Szakal, Analyst, 2012, 137, 3479
    DOI: 10.1039/C2AN16122B

Search articles by author

Spotlight

Advertisements