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Issue 23, 2011
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Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

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Abstract

In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.

Graphical abstract: Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

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Publication details

The article was received on 19 Jul 2011, accepted on 23 Sep 2011 and first published on 17 Oct 2011


Article type: Paper
DOI: 10.1039/C1SM06357J
Citation: Soft Matter, 2011,7, 11259-11266
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    Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

    J. C. Cuggino, C. I. Alvarez I., M. C. Strumia, P. Welker, K. Licha, D. Steinhilber, R. Mutihac and M. Calderón, Soft Matter, 2011, 7, 11259
    DOI: 10.1039/C1SM06357J

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