Issue 20, 2011

The physics of tissue patterning and extracellular matrix organisation: how cells join forces

Abstract

This paper reviews recent literature about the physical processes involved in cell interactions and tissue development. Rather than being exhaustive, we intend to provide illustrative examples of experiments and theoretical approaches into how cells interact with other cells and with substrates to form complex tissues and organs. Forces and geometry efficiently coordinate cell behaviour through feedback and mechanical homeostasis, leading to emergent properties not directly evident from the behaviour of individual cells. Two important examples for such emergent properties are the patterning of growth and differentiation within tissues, and the long-range organisation of the extracellular matrix. Despite the complexity of the biological, chemical and mechanical processes involved, theoretical studies have shown that many of these phenomena can be described quantitatively by simple physical processes, such as surface tension controlled growth. In addition to improving knowledge about the biology of tissues, a thorough theoretical understanding of the self-organising mechanisms used by nature may provide inspiration for the design of self-assembling biomimetic soft materials.

Graphical abstract: The physics of tissue patterning and extracellular matrix organisation: how cells join forces

Article information

Article type
Review Article
Submitted
04 Apr 2011
Accepted
23 May 2011
First published
07 Jul 2011

Soft Matter, 2011,7, 9549-9560

The physics of tissue patterning and extracellular matrix organisation: how cells join forces

P. Kollmannsberger, C. M. Bidan, J. W. C. Dunlop and P. Fratzl, Soft Matter, 2011, 7, 9549 DOI: 10.1039/C1SM05588G

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