Issue 18, 2011
From the journal:

Soft Matter

Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids†

Alexandra Zidovska,*abc   Kai K. Ewert,a   Joel Quispe,d   Bridget Carragher,d   Clinton S. Potterd  and  Cyrus R. Safinya*a  

* Corresponding authors

a Materials, Physics, and Molecular, Cellular and Developmental Biology Departments, University of California at Santa Barbara, Santa Barbara, CA, USA
E-mail: alexandra_zidovska@hms.harvard.edu, safinya@mrl.ucsb.edu

b Dept. of Systems Biology, Harvard Medical School, Boston, MA, USA

c School of Engineering and Applied Sciences/Dept. of Physics, Harvard University, Cambridge, MA, USA

d National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA

Abstract

We report a study on the formation of block liposomes (BLs) and nanotubes from membranes comprising mixtures of membrane curvature-stabilizing multivalent cationic lipids MVL3(3+) and MVL5(5+) with neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In conjunction with prior work on MVLBG2(16+), our experiments suggest that BL and nanotube formation is a general phenomenon in membranes containing multivalent lipids, thus enhancing the relevance of BLs for applications such as gene/drug storage and delivery or templating.

Graphical abstract: Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1SM05481C
Article type
Paper
Submitted
20 Mar 2011
Accepted
12 May 2011
First published
20 Jun 2011

Soft Matter, 2011,7, 8363-8369

Permissions

Request permissions

Block liposome and nanotube formation is a general phenomenon of two-component membranes containing multivalent lipids

A. Zidovska, K. K. Ewert, J. Quispe, B. Carragher, C. S. Potter and C. R. Safinya, Soft Matter, 2011, 7, 8363 DOI: 10.1039/C1SM05481C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements