Issue 6, 2011
From the journal:

Soft Matter

Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release†

Tian-Bin Ren,a   Yue Feng,a   Zhong-Hai Zhang,a   Lan Lia  and  Yong-Yong Li*b  

* Corresponding authors

a Institute of Nano- and Bio-polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, PR China

b The Institute for Advanced Materials & Nano Biomedicine, Tongji University, Shanghai, PR China
E-mail: yongyong_li@tongji.edu.cn, rtb002@tongji.edu.cn

Abstract

We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(ε-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.

Graphical abstract: Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

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Article information

DOI
https://doi.org/10.1039/C1SM05020F
Article type
Communication
Submitted
07 Jan 2011
Accepted
24 Jan 2011
First published
15 Feb 2011

Soft Matter, 2011,7, 2329-2331

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Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

T. Ren, Y. Feng, Z. Zhang, L. Li and Y. Li, Soft Matter, 2011, 7, 2329 DOI: 10.1039/C1SM05020F

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