Issue 11, 2011
From the journal:

Soft Matter

Self-assembling drugs: A new therapeutic strategy†

Natalia Hassan,a   Juan M. Rusoa  and  Alfredo González-Pérez*b  

* Corresponding authors

a Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, Campus Sur s/n, Santiago de Compostela, Spain

b Membrane Biophysics Group, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, Copenhagen, Denmark
E-mail: gonzalez@nbi.ku.dk, alfredogp@gmail.com
Web: http://www.gonzalez-perez.sitew.com/

Abstract

In the current work we proposed the new idea of “self-assembled drug” based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

Graphical abstract: Self-assembling drugs: A new therapeutic strategy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0SM01529F
Article type
Paper
Submitted
22 Dec 2010
Accepted
31 Mar 2011
First published
03 May 2011

Soft Matter, 2011,7, 5194-5199

Permissions

Request permissions

Self-assembling drugs: A new therapeutic strategy

N. Hassan, J. M. Ruso and A. González-Pérez, Soft Matter, 2011, 7, 5194 DOI: 10.1039/C0SM01529F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements