Issue 10, 2011
From the journal:

Soft Matter

Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs†

Li Liu,a   Jian-Ping Yang,a   Xiao-Jie Ju,a   Rui Xie,a   Ying-Mei Liu,a   Wei Wang,a   Jin-Jin Zhang,a   Catherine Hui Niub  and  Liang-Yin Chu*a  

* Corresponding authors

a School of Chemical Engineering, Sichuan University, Chengdu, Sichuan, China
E-mail: chuly@scu.edu.cn
Tel: +86 28 8546 0682

b Department of Chemical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, Canada

Abstract

Monodisperse core-shell microcapsules based on crosslinked chitosan membrane with acid-triggered burst release properties are successfully developed. The microcapsules are fabricated from double emulsion precursors that are prepared with a microfluidic approach. In neutral medium (pH 7.1), the microcapsules maintain a good spherical shape and structural integrity; while, in acidic medium (pH 1.5 ∼ 4.7), the microcapsules decompose rapidly and release the encapsulated contents completely in short periods varying from 39 s to 22 min. The acid-triggered burst release pattern from the proposed chitosan microcapsules may make them capable for stomach-specific drug delivery systems with quick and complete release characteristics in a controllable pH-responsive manner.

Graphical abstract: Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs

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Article information

DOI
https://doi.org/10.1039/C0SM01393E
Article type
Paper
Submitted
30 Nov 2010
Accepted
01 Mar 2011
First published
31 Mar 2011

Soft Matter, 2011,7, 4821-4827

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Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs

L. Liu, J. Yang, X. Ju, R. Xie, Y. Liu, W. Wang, J. Zhang, C. H. Niu and L. Chu, Soft Matter, 2011, 7, 4821 DOI: 10.1039/C0SM01393E

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