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Issue 10, 2011
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Nickel-catalyzed cross coupling of non-activated alkyl halides: a mechanistic perspective

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Abstract

Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism of these coupling reactions is highlighted. As the mechanism is ligand-dependant, the perspective is organized according to the types of ligands employed in the catalysis.

Graphical abstract: Nickel-catalyzed cross coupling of non-activated alkyl halides: a mechanistic perspective

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Publication details

The article was received on 15 Jun 2011, accepted on 22 Jul 2011 and first published on 15 Aug 2011


Article type: Perspective
DOI: 10.1039/C1SC00368B
Citation: Chem. Sci., 2011,2, 1867-1886
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    Nickel-catalyzed cross coupling of non-activated alkyl halides: a mechanistic perspective

    X. Hu, Chem. Sci., 2011, 2, 1867
    DOI: 10.1039/C1SC00368B

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