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Issue 8, 2011
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Au@organosilica multifunctional nanoparticles for the multimodal imaging

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Abstract

The increasing application of nanomaterials in biosensor and imaging sets a higher demand on the multifunctionalities of nanomaterials for obtaining multiple parameters of a same system under a same condition. In this work, multifunctional Au@organosilica nanoparticles with high stability were conveniently synthesized by direct hydrolyzing of 3-mercaptopropyltriethoxysilane in an aqueous solution in the presence of a Au core. Modification of the Au core with Raman reporters and the organosilica shell with fluorophore before and after the hydrolysis, respectively, produces multifunctional nanoparticles exhibiting Rayleigh scattering of the Au core, fluorescence signals of the fluorophores and surface-enhanced Raman scattering (SERS) of the Raman reporters. The nanoparticles can be used as multimodal tracers for living cell imaging and related biological research.

Graphical abstract: Au@organosilica multifunctional nanoparticles for the multimodal imaging

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Publication details

The article was received on 18 Apr 2011, accepted on 31 May 2011 and first published on 23 Jun 2011


Article type: Edge Article
DOI: 10.1039/C1SC00242B
Chem. Sci., 2011,2, 1463-1469

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    Au@organosilica multifunctional nanoparticles for the multimodal imaging

    Y. Cui, X. Zheng, B. Ren, R. Wang, J. Zhang, N. Xia and Z. Tian, Chem. Sci., 2011, 2, 1463
    DOI: 10.1039/C1SC00242B

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