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Issue 10, 2011
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Sensing coiled-coil proteins through conformational modulation of energy transfer processes – selective detection of the oncogenic transcription factor c-Jun

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Abstract

Designed terbium-chelating peptides were used to monitor the formation of leucine zipper associations. The sensing strategy is based on the modulation of the antenna effect from a Trp residue donor and the luminescence increase arising from the folding that takes place upon the formation of the coiled-coil structure. An application in the specific sensing of the oncogenic c-Jun transcription factor is demonstrated.

Graphical abstract: Sensing coiled-coil proteins through conformational modulation of energy transfer processes – selective detection of the oncogenic transcription factor c-Jun

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Supplementary files

Article information


Submitted
23 Feb 2011
Accepted
05 Jul 2011
First published
21 Jul 2011

Chem. Sci., 2011,2, 1984-1987
Article type
Edge Article

Sensing coiled-coil proteins through conformational modulation of energy transfer processes – selective detection of the oncogenic transcription factor c-Jun

E. Pazos, A. Jiménez-Balsa, J. L. Mascareñas and M. E. Vázquez, Chem. Sci., 2011, 2, 1984
DOI: 10.1039/C1SC00108F

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