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Issue 9, 2011
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Protein–dendron conjugates for DNA binding: understanding the effect of the protein core on multivalency

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Abstract

In this work we have used molecular dynamics simulations to explore the binding between two different protein–dendron conjugates and double stranded DNA. Different protein cores protect the binding site from the external environment, but can also influence the multivalent recognition between the spermine ligands of the dendron and the DNA.

Graphical abstract: Protein–dendron conjugates for DNA binding: understanding the effect of the protein core on multivalency

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Supplementary files

Article information


Submitted
17 Jul 2011
Accepted
28 Sep 2011
First published
24 Oct 2011

RSC Adv., 2011,1, 1677-1681
Article type
Communication

Protein–dendron conjugates for DNA binding: understanding the effect of the protein core on multivalency

G. M. Pavan, M. A. Kostiainen and A. Danani, RSC Adv., 2011, 1, 1677
DOI: 10.1039/C1RA00472G

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