Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Simple and efficient copper metal-mediated synthesis of alkoxyamine initiators

Author affiliations

Abstract

A simple and efficient method is presented for the preparation of a wide range of alkoxyamines from nitroxide radicals and activated alkyl bromides at room temperature. The reaction requires a stoichiometric amount of copper metal (0.5 mol mol−1 alkyl bromide) and proceeds most rapidly in polar solvents such as acetonitrile, dimethyl sulfoxide or ethanol. No addition of copper(I) or copper(II) salts is necessary. Isolated yields of 71–94% were obtained across a range of alkyl bromide and nitroxide substrates, with reaction times of 1–16 h. The method is compatible with carboxylic acid and amine functionalities.

Graphical abstract: Simple and efficient copper metal-mediated synthesis of alkoxyamine initiators

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Mar 2011, accepted on 28 Apr 2011 and first published on 27 May 2011


Article type: Paper
DOI: 10.1039/C1PY00131K
Polym. Chem., 2011,2, 1859-1865

  •   Request permissions

    Simple and efficient copper metal-mediated synthesis of alkoxyamine initiators

    S. Harrisson, P. Couvreur and J. Nicolas, Polym. Chem., 2011, 2, 1859
    DOI: 10.1039/C1PY00131K

Search articles by author

Spotlight

Advertisements