Issue 7, 2011
From the journal:

Polymer Chemistry

FDA-approved poly(ethylene glycol)–protein conjugate drugs

Steevens N. S. Alconcel,a   Arnold S. Baas*b  and  Heather D. Maynard*a  

* Corresponding authors

a Department of Chemistry & Biochemistry and the California NanoSystems Institute, University of California, 607 Charles E. Young Dr East, Los Angeles, CA, USA
E-mail: maynard@chem.ucla.edu

b Ronald Reagan UCLA Medical Center, Division of Cardiology, 757 Westwood Plaza, Los Angeles, CA, USA
E-mail: abaas@mednet.ucla.edu

Abstract

PEGylation or covalent attachment of poly(ethylene glycol) improves the pharmacokinetic properties of protein drugs. In vivo circulation lifetimes are increased and dosages are decreased, resulting in improved patient quality of life. PEG may be attached to proteins using a variety of different chemical reactions. This review discusses currently available FDA-approved PEGylated protein drugs, their intended use and target, and the PEG attachment chemistry utilized.

Graphical abstract: FDA-approved poly(ethylene glycol)–protein conjugate drugs

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Article information

DOI
https://doi.org/10.1039/C1PY00034A
Article type
Review Article
Submitted
21 Jan 2011
Accepted
20 Mar 2011
First published
27 Apr 2011

Polym. Chem., 2011,2, 1442-1448

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FDA-approved poly(ethylene glycol)–protein conjugate drugs

S. N. S. Alconcel, A. S. Baas and H. D. Maynard, Polym. Chem., 2011, 2, 1442 DOI: 10.1039/C1PY00034A

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