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Issue 9, 2011
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Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Matthias Barz,†*ab   Robert Luxenhofer,†*c   Rudolf Zentelb  and  María J. Vicenta  
Author affiliations

* Corresponding authors

a Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Avda Autopista del Saler 16/3, Valencia, Spain
E-mail: mbarz@cipf.es
Fax: +34 963289701
Tel: +34 963289680

b Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, Mainz, Germany
E-mail: barz@uni-mainz.de
Fax: +49 6131 39 24778
Tel: +49 6131 39 25468

c Professur für Makromolekulare Chemie, Department Chemie, Technische Universität Dresden, Zellescher Weg 19, Dresden, Germany
E-mail: robert.luxenhofer@chemie.tu-dresden.de
Fax: +49 351 463 37122
Tel: +49 351 463 36057

Abstract

Synthetic methods in polymer chemistry have evolved tremendously during the last decade. Nowadays more and more attention is devoted to the application of those tools in the development of the next generation of nanomedicines. Nevertheless, poly(ethylene glycol) (PEG) remains the most frequently used polymer for biomedical applications. In this review, we try to summarize recent efforts and developments in controlled polymerisation techniques that may allow alternatives to PEG based systems and can be used to improve the properties of future polymer therapeutics.

Graphical abstract: Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

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Article information

https://doi.org/10.1039/C0PY00406E
Submitted
15 Dec 2010
Accepted
15 Feb 2011
First published
28 Mar 2011
Polym. Chem., 2011,2, 1900-1918
Article type
Review Article
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Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

M. Barz, R. Luxenhofer, R. Zentel and M. J. Vicent, Polym. Chem., 2011, 2, 1900
DOI: 10.1039/C0PY00406E

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