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Issue 9, 2011
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Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Matthias Barz,*ab  Robert Luxenhofer,*c  Rudolf Zentelb  and  María J. Vicenta 
Author affiliations

* Corresponding authors

a Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Avda Autopista del Saler 16/3, Valencia, Spain
E-mail: mbarz@cipf.es
Fax: +34 963289701
Tel: +34 963289680

b Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, Mainz, Germany
E-mail: barz@uni-mainz.de
Fax: +49 6131 39 24778
Tel: +49 6131 39 25468

c Professur für Makromolekulare Chemie, Department Chemie, Technische Universität Dresden, Zellescher Weg 19, Dresden, Germany
E-mail: robert.luxenhofer@chemie.tu-dresden.de
Fax: +49 351 463 37122
Tel: +49 351 463 36057

Abstract

Synthetic methods in polymer chemistry have evolved tremendously during the last decade. Nowadays more and more attention is devoted to the application of those tools in the development of the next generation of nanomedicines. Nevertheless, poly(ethylene glycol) (PEG) remains the most frequently used polymer for biomedical applications. In this review, we try to summarize recent efforts and developments in controlled polymerisation techniques that may allow alternatives to PEG based systems and can be used to improve the properties of future polymer therapeutics.

Graphical abstract: Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

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Publication details

The article was received on 15 Dec 2010, accepted on 15 Feb 2011 and first published on 28 Mar 2011


Article type: Review Article
DOI: 10.1039/C0PY00406E
Citation: Polym. Chem., 2011,2, 1900-1918
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    Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

    M. Barz, R. Luxenhofer, R. Zentel and M. J. Vicent, Polym. Chem., 2011, 2, 1900
    DOI: 10.1039/C0PY00406E

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