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Issue 1, 2011
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Main-chain chiral copoly(2-oxazoline)s

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(Chiral) poly(2-oxazoline)s are regarded as pseudo-polypeptides, however, not much is known about their secondary structure formation. Recently we reported that chiral homopolymers based on R- and S-2-butyl-4-ethyl-2-oxazoline (BuEtOx) monomers form flexible dynamic helices in solution (Soft Matter, 2010, 6, 994–1003) and a chiral crystalline structure in the solid state (Macromolecules, 2010, 43, 4654–4659). In the current work we addressed the chiral structure formation of main-chain chiral copoly(2-oxazoline)s with controlled ratio of S-BuEtOx and R-BuEtOx. No chiral amplification was found in solution or in the solid state, clearly indicating that the polymers adopt a dynamic helical structure that is easily disrupted by incorporation of the second monomer. Nonetheless, the properties of these main-chain chiral copoly(2-oxazoline)s, such as the optical rotation, solubility and crystallinity, can be tuned by controlling the enantiomeric excess (ee).

Graphical abstract: Main-chain chiral copoly(2-oxazoline)s

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The article was received on 18 Aug 2010, accepted on 15 Sep 2010 and first published on 01 Nov 2010

Article type: Paper
DOI: 10.1039/C0PY00264J
Polym. Chem., 2011,2, 203-208

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    Main-chain chiral copoly(2-oxazoline)s

    M. M. Bloksma, U. S. Schubert and R. Hoogenboom, Polym. Chem., 2011, 2, 203
    DOI: 10.1039/C0PY00264J

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