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Abstract | Cited by

A one-pot two-step microwave assisted synthesis of variously disubstituted 1,2,4-oxadiazoles from carboxylic acids and amidoximes is reported. This methodology is characterized by short reaction times, is versatile, robust and high-yielding and allows for the preparation of heterocycles with a stereocenter with 100% enantiomeric purity.

Graphical abstract: A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

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