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Issue 22, 2011
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Rational design of a cyclin A fluorescent peptide sensor

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Abstract

We report the design and development of a fluorescent sensor specifically designed to target cyclin A, a protein that plays a key role in the regulation of the cell cycle. Computational studies provide a molecular picture that explains the observed emission increase, suggesting that the 4-DMAP fluorophore in the peptide is protected from the bulk solvent when inserted into the hydrophobic binding groove of cyclin A.

Graphical abstract: Rational design of a cyclin A fluorescent peptide sensor

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Article information


Submitted
23 Jun 2011
Accepted
05 Aug 2011
First published
23 Aug 2011

Org. Biomol. Chem., 2011,9, 7629-7632
Article type
Communication

Rational design of a cyclin A fluorescent peptide sensor

E. Pazos, M. Pérez, H. Gutiérrez-de-Terán, M. Orzáez, T. Guevara, J. L. Mascareñas and M. E. Vázquez, Org. Biomol. Chem., 2011, 9, 7629
DOI: 10.1039/C1OB06009K

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