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Issue 22, 2011
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The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

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Abstract

The unique antibacterial properties and structural complexity of the lantibiotics has stimulated considerable interest in the development of methodology to synthesise these peptides. One of the most challenging issues has been the synthesis of polycyclic peptides with multiple thioether bridges between side-chains, which are a characteristic feature of the lantibiotics. In this perspective, the different approaches to this problem, including solution-phase synthesis, solid-phase synthesis, biomimetic approaches and biotransformation strategies, are reviewed, highlighting the advances resulting from each of these approaches.

Graphical abstract: The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

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Publication details

The article was received on 11 Jun 2011, accepted on 04 Aug 2011 and first published on 29 Sep 2011


Article type: Perspective
DOI: 10.1039/C1OB05946G
Org. Biomol. Chem., 2011,9, 7606-7628

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    The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

    A. B. Tabor, Org. Biomol. Chem., 2011, 9, 7606
    DOI: 10.1039/C1OB05946G

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