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Issue 15, 2011
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Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

Maravanhalli Sidde Gowda,a  Sushanth Sudhir Pande,b  Ramesha Andagar Ramakrishna*a  and  Kandikere Ramaiah Prabhu*b 
Author affiliations

* Corresponding authors

a R. L. Fine Chem, No. 15, KHB Industrial Area, Yelahanka Newtown, Bangalore, India
E-mail: ramesha63@hotmail.com

b Department of Organic Chemistry, Indian Institute of Science, Bangalore, India
E-mail: prabhu@orgchem.iisc.ernet.in
Fax: (+) 91-80-23600529
Tel: (+) 91-80-22932887

Abstract

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

Graphical abstract: Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

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Publication details

The article was received on 14 Mar 2011, accepted on 01 Jun 2011 and first published on 01 Jun 2011


Article type: Communication
DOI: 10.1039/C1OB05780D
Org. Biomol. Chem., 2011,9, 5365-5368

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    Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

    M. S. Gowda, S. S. Pande, R. A. Ramakrishna and K. R. Prabhu, Org. Biomol. Chem., 2011, 9, 5365
    DOI: 10.1039/C1OB05780D

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