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Issue 15, 2011
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Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

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Abstract

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

Graphical abstract: Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

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Supplementary files

Article information


Submitted
14 Mar 2011
Accepted
01 Jun 2011
First published
01 Jun 2011

Org. Biomol. Chem., 2011,9, 5365-5368
Article type
Communication

Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

M. S. Gowda, S. S. Pande, R. A. Ramakrishna and K. R. Prabhu, Org. Biomol. Chem., 2011, 9, 5365 DOI: 10.1039/C1OB05780D

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