Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

γ-AApeptides bind to RNA by mimicking RNA-binding proteins†

Youhong Niu,‡a   Alisha “Jonesy” Jones,‡b   Haifan Wu,a   Gabriele Varani*bc  and  Jianfeng Cai*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL, USA
E-mail: jianfengcai@usf.edu

b Department of Chemistry, University of Washington, Box 351700, Seattle, WA, USA

c Department of Biochemistry, University of Washington, Box 357350, Seattle, WA, USA
E-mail: varani@chem.washington.edu

Abstract

The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of Tat (amino acids 49–58). The interaction is resistant to the presence of a large excess of tRNA. With resistance to proteolytic hydrolysis and limitless potential for diversification, γ-AApeptides may emerge as a new class of peptidomimetics to modulate RNA-protein interactions.

Graphical abstract: γ-AApeptides bind to RNA by mimicking RNA-binding proteins

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Article information

DOI
https://doi.org/10.1039/C1OB05738C
Article type
Paper
Submitted
11 May 2011
Accepted
01 Jul 2011
First published
01 Jul 2011

Org. Biomol. Chem., 2011,9, 6604-6609

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γ-AApeptides bind to RNA by mimicking RNA-binding proteins

Y. Niu, A. “. Jones, H. Wu, G. Varani and J. Cai, Org. Biomol. Chem., 2011, 9, 6604 DOI: 10.1039/C1OB05738C

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