Issue 15, 2011
From the journal:

Organic & Biomolecular Chemistry

A rapid and convergent synthesis of the integrastatin core†

Pamela M. Tadross,a   Pradeep Buggaa  and  Brian M. Stoltz*a  

* Corresponding authors

a The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA, USA
E-mail: stoltz@caltech.edu
Fax: +1-626-395-8436
Tel: +1-626-395-6064

Abstract

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

Graphical abstract: A rapid and convergent synthesis of the integrastatin core

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Article information

DOI
https://doi.org/10.1039/C1OB05725A
Article type
Communication
Submitted
08 May 2011
Accepted
26 May 2011
First published
26 May 2011

Org. Biomol. Chem., 2011,9, 5354-5357

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A rapid and convergent synthesis of the integrastatin core

P. M. Tadross, P. Bugga and B. M. Stoltz, Org. Biomol. Chem., 2011, 9, 5354 DOI: 10.1039/C1OB05725A

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