Issue 18, 2011
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines†

Abdallah Hamze,*a   Bret Tréguier,a   Jean-Daniel Briona  and  Mouâd Alami*a  

* Corresponding authors

a Univ Paris-Sud 11, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, France
E-mail: abdallah.hamze@u-psud.fr, mouad.alami@u-psud.fr
Fax: +33-1-46835828
Tel: +33-1-46835887

Abstract

A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)2 and Cs2CO3 has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.

Graphical abstract: Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

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Article information

DOI
https://doi.org/10.1039/C1OB05664F
Article type
Communication
Submitted
28 Apr 2011
Accepted
06 Jul 2011
First published
12 Jul 2011

Org. Biomol. Chem., 2011,9, 6200-6204

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Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

A. Hamze, B. Tréguier, J. Brion and M. Alami, Org. Biomol. Chem., 2011, 9, 6200 DOI: 10.1039/C1OB05664F

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