Issue 16, 2011

Structure-related variable responses of calcium sensitive MRI probes

Abstract

A new series of Gd3+ complexes based on DO3A (GdL1GdL4) was synthesized and investigated. They possess side chains with different structures which determine their varying binding properties and response towards endogenous metal ions, measured by changes in the longitudinal relaxivity (r1). GdL4 exhibits the highest selectivity toward Ca2+ in comparison to the other complexes, with up to a 63% increase of the r1. GdL2 and GdL3 also respond to different Ca2+ concentration ranges, however with a lower selectivity since the r1 changes are also observed in the presence of other cations such as Mg2+, Zn2+ or Cu2+. Assessment of the hydration number (q) via luminescence lifetime measurements confirmed that the change in q is responsible for the r1 response for all the complexes.

Graphical abstract: Structure-related variable responses of calcium sensitive MRI probes

Article information

Article type
Paper
Submitted
23 Mar 2011
Accepted
13 May 2011
First published
16 May 2011

Org. Biomol. Chem., 2011,9, 5816-5824

Structure-related variable responses of calcium sensitive MRI probes

I. Mamedov, N. K. Logothetis and G. Angelovski, Org. Biomol. Chem., 2011, 9, 5816 DOI: 10.1039/C1OB05463E

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