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Issue 14, 2011
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Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

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Abstract

A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

Graphical abstract: Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

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Article information


Submitted
21 Mar 2011
Accepted
28 Apr 2011
First published
28 Apr 2011

Org. Biomol. Chem., 2011,9, 5280-5287
Article type
Paper

Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

J. Chen, L. Fu, Y. Zou, N. Chang, J. Rong and W. Xiao, Org. Biomol. Chem., 2011, 9, 5280
DOI: 10.1039/C1OB05442B

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