Issue 12, 2011
From the journal:

Organic & Biomolecular Chemistry

One step entry to P,O- and P,N-type heterocyclic tertiary phosphineligands and application in Suzuki–Miyaura cross-coupling reactions†

Ehsan Ullah,a   James McNulty,*a   Christine Kennedyb  and  Al Robertsonb  

* Corresponding authors

a Department of Chemistry, McMaster University, Hamilton, Ontario, Canada
E-mail: jmcnult@mcmaster.ca
Fax: (+1)-905-522 2509
Tel: (+1)-905-525-9140 Ext. 27393

b Cytec Canada, Inc., P.O. Box 240, Niagara Falls, Ontario, Canada

Abstract

A direct synthesis of conformationally mobile P,O- and P,N-type heterocyclic phosphine ligands is described involving radical-mediated addition of diisobutylphosphine to olefinic-heterocycles. Palladium complexes of the P,N-ligand were determined to be highly active in the Suzuki–Miyaura cross-coupling reactions, including deactivated aryl chlorides.

Graphical abstract: One step entry to P,O- and P,N-type heterocyclic tertiary phosphine ligands and application in Suzuki–Miyaura cross-coupling reactions

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Article information

DOI
https://doi.org/10.1039/C1OB05426K
Article type
Communication
Submitted
17 Mar 2011
Accepted
20 Apr 2011
First published
21 Apr 2011

Org. Biomol. Chem., 2011,9, 4421-4424

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One step entry to P,O- and P,N-type heterocyclic tertiary phosphine ligands and application in Suzuki–Miyaura cross-coupling reactions

E. Ullah, J. McNulty, C. Kennedy and A. Robertson, Org. Biomol. Chem., 2011, 9, 4421 DOI: 10.1039/C1OB05426K

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