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Issue 17, 2011
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A facile preparation of trisubstituted amino-furan and -thiophene derivatives

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Abstract

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon–carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.

Graphical abstract: A facile preparation of trisubstituted amino-furan and -thiophene derivatives

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Publication details

The article was received on 09 Feb 2011, accepted on 06 Jun 2011 and first published on 06 Jun 2011


Article type: Paper
DOI: 10.1039/C1OB05216K
Org. Biomol. Chem., 2011,9, 6055-6065

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    A facile preparation of trisubstituted amino-furan and -thiophene derivatives

    R. Medimagh, S. Marque, D. Prim and S. Chatti, Org. Biomol. Chem., 2011, 9, 6055
    DOI: 10.1039/C1OB05216K

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