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Issue 10, 2011
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N-Heterocyclic carbene-catalyzed [4 + 1] annulation of phthalaldehyde and imines

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Abstract

The diastereoselective synthesis of cis-2-amino-3-hydroxyindanones was realized by the N-heterocyclic carbene-catalyzed [4 + 1] annulation of phthalaldehyde and imines, which may involve a tandem aza-benzoin reaction and aldol reaction.

Graphical abstract: N-Heterocyclic carbene-catalyzed [4 + 1] annulation of phthalaldehyde and imines

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Article information


Submitted
18 Jan 2011
Accepted
23 Mar 2011
First published
24 Mar 2011

Org. Biomol. Chem., 2011,9, 3632-3635
Article type
Communication

N-Heterocyclic carbene-catalyzed [4 + 1] annulation of phthalaldehyde and imines

F. Sun and S. Ye, Org. Biomol. Chem., 2011, 9, 3632
DOI: 10.1039/C1OB05092C

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