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Issue 16, 2011
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Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity

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Abstract

It has been revealed for the first time that sodium fullerenolate Na4[C60(OH)∼30] (NaFL), a water soluble polyhydroxylated [60]fullerene derivative, destroys amyloid fibrils of the Aβ(1–42) peptide in the brain and prevents their formation in in vitro experiments. The cytotoxicity of NaFL was found to be negligibly low with respect to nine different culture cell lines. At the same time, NaFL showed a very low acute toxicity in vivo. The maximal tolerable dose (MTD) and LD50 for NaFL correspond to 1000 mg kg−1 and 1800 mg kg−1, respectively, as revealed by in vivo tests in mice using intraperitoneal drug injection. The observed pronounced anti-amyloid activity and low toxicity of NaFL make it a very promising lead drug for the development of potent fullerene-based therapeutic approaches for the treatment of amyloidoses, such as Alzheimer's disease and others.

Graphical abstract: Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity

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Supplementary files

Article information


Submitted
12 Jan 2011
Accepted
26 Apr 2011
First published
27 Apr 2011

Org. Biomol. Chem., 2011,9, 5714-5719
Article type
Paper

Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity

A. G. Bobylev, A. B. Kornev, L. G. Bobyleva, M. D. Shpagina, I. S. Fadeeva, R. S. Fadeev, D. G. Deryabin, J. Balzarini, P. A. Troshin and Z. A. Podlubnaya, Org. Biomol. Chem., 2011, 9, 5714
DOI: 10.1039/C1OB05067B

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