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Issue 7, 2011
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A stereoselective, Sm(ii)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

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Abstract

The cis-hydrindane motif is found in a number of natural products that display important biological activity. A flexible, stereoselective approach to the framework has been developed that features highly diastereoselective, SmI2-mediated cyclisations. The strategy has been exploited in the first synthesis of the proposed structure of faurinone and an approach to the skeleton of the antibacterial natural product, pleuromutilin.

Graphical abstract: A stereoselective, Sm(ii)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

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Article information


Submitted
25 Nov 2010
Accepted
05 Jan 2011
First published
07 Jan 2011

Org. Biomol. Chem., 2011,9, 2433-2451
Article type
Paper

A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

T. J. K. Findley, D. Sucunza, L. C. Miller, M. D. Helm, M. Helliwell, D. T. Davies and D. J. Procter, Org. Biomol. Chem., 2011, 9, 2433
DOI: 10.1039/C0OB01086C

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