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Issue 2, 2011

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

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Abstract

A highly efficient enantioselective SNAr reaction of chiral acyl bicyclic lactam with substituted-2,4-dinitrobenzenes was developed, affording products containing quarternary stereogenic centers. They are further utilized towards an enantioselective synthesis of spirooxoindoles.

Graphical abstract: Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

Supplementary files

Article information


Submitted
03 Sep 2010
Accepted
13 Oct 2010
First published
14 Oct 2010

Org. Biomol. Chem., 2011,9, 358-360
Article type
Communication

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

S. Sen, V. R. Potti, R. Surakanti, Y. L. N. Murthy and R. Pallepogu, Org. Biomol. Chem., 2011, 9, 358 DOI: 10.1039/C0OB00661K

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