A cationic ZnII porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA

Ilse Manet; Francesco Manoli; Maria Pia Donzello; Elisa Viola; Giuseppina Andreano; Annalisa Masi; Luciano Cellai; Sandra Monti

doi:10.1039/C0OB00598C

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A cationic Zn^IIporphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA†

Ilse Manet,*^a Francesco Manoli,^a Maria Pia Donzello,*^b Elisa Viola,^b Giuseppina Andreano,^c Annalisa Masi,^c Luciano Cellai^c and Sandra Monti*^a

Author affiliations

* Corresponding authors

^a Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, via Gobetti 101, 40129 Bologna, Italy

^b Dipartimento di Chimica, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, 00185 Rome, Italy

^c Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area della Ricerca di Roma 1, 00015 Monterotondo Scalo, Rome, Italy

Abstract

A water solubleZn^II porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation.

This article is part of the themed collection: Chemical Biology

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Article information

DOI: https://doi.org/10.1039/C0OB00598C
Article type: Communication
Submitted: 18 Aug 2010
Accepted: 03 Nov 2010
First published: 08 Nov 2010

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Org. Biomol. Chem., 2011,9, 684-688

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A cationic Zn^II porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA

I. Manet, F. Manoli, M. P. Donzello, E. Viola, G. Andreano, A. Masi, L. Cellai and S. Monti, Org. Biomol. Chem., 2011, 9, 684 DOI: 10.1039/C0OB00598C

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Organic & Biomolecular Chemistry