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Issue 7, 2011
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Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

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Abstract

Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes to retain their activity, affording them greater potential for wide applications in biocatalysis and energy. This review provides a comprehensive summary of the advances made in the last decade and a future outlook on possible applications of MSNs as nanocontainers for storage and delivery of biomolecules. We discuss some of the important factors affecting the adsorption and release of biomolecules in MSNs and review of the cytotoxicity aspects of such nanomaterials. The review also highlights some promising work on enzyme immobilisation using mesoporous silica nanoparticles.

Graphical abstract: Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

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Publication details

The article was received on 01 Mar 2011, accepted on 29 Mar 2011 and first published on 05 May 2011


Article type: Review Article
DOI: 10.1039/C1NR10224A
Citation: Nanoscale, 2011,3, 2801-2818

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    Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

    A. Popat, S. B. Hartono, F. Stahr, J. Liu, S. Z. Qiao and G. Qing (Max) Lu, Nanoscale, 2011, 3, 2801
    DOI: 10.1039/C1NR10224A

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