Jump to main content
Jump to site search

Issue 7, 2011
Previous Article Next Article

Mesoporous silicananoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

Author affiliations

Abstract

Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes to retain their activity, affording them greater potential for wide applications in biocatalysis and energy. This review provides a comprehensive summary of the advances made in the last decade and a future outlook on possible applications of MSNs as nanocontainers for storage and delivery of biomolecules. We discuss some of the important factors affecting the adsorption and release of biomolecules in MSNs and review of the cytotoxicity aspects of such nanomaterials. The review also highlights some promising work on enzyme immobilisation using mesoporous silica nanoparticles.

Graphical abstract: Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

Back to tab navigation

Article information


Submitted
01 Mar 2011
Accepted
29 Mar 2011
First published
05 May 2011

Nanoscale, 2011,3, 2801-2818
Article type
Review Article

Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

A. Popat, S. B. Hartono, F. Stahr, J. Liu, S. Z. Qiao and G. Qing (Max) Lu, Nanoscale, 2011, 3, 2801
DOI: 10.1039/C1NR10224A

Social activity

Search articles by author

Spotlight

Advertisements