Iron homeostasis and management of oxidative stress response in bacteria

Pierre Cornelis; Qing Wei; Simon C. Andrews; Tiffany Vinckx

doi:10.1039/C1MT00022E

Iron homeostasis and management of oxidative stress response in bacteria

Pierre Cornelis,*^a Qing Wei,^a Simon C. Andrews^b and Tiffany Vinckx^a

* Corresponding authors

^a Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
E-mail: pcornel@vub.ac.be

^b School of Biological Sciences, Whiteknights, University of Reading, Reading, UK

Abstract

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction. For these reasons, bacteria must tightly control the uptake and storage of iron in a manner that restricts the build-up of ROS. Therefore, it is not surprising to find that the control of iron homeostasis and responses to oxidative stress are coordinated. The mechanisms concerned with these processes, and the interactions involved, are the subject of this review.

Metallomics

Iron homeostasis and management of oxidative stress response in bacteria

Abstract

Article information

Download Citation

Search articles by author

Spotlight

Advertisements