Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
E-mail:Max.Cryle@mpimf-heidelberg.mpg.de Fax: 49 6221 486585 Tel: 49 6221 486536
Enzymes of the cytochrome P450 superfamily can catalyse many types of oxidative transformations of a diverse substrate range. This review summarises recent work on an subset of P450s that accept their substrates in carrier protein-bound form. These examples show how the oxidative power and precision that P450s bring to natural products biosynthesis can be coupled with the advantages of using a carrier protein as a scaffold for oxidation.
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