Issue 7, 2011

Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivoantimalarial activities

Abstract

A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. bergheiANKA mouse model of malaria.

Graphical abstract: Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivoantimalarial activities

Supplementary files

Article information

Article type
Concise Article
Submitted
15 Apr 2011
Accepted
10 May 2011
First published
09 Jun 2011

Med. Chem. Commun., 2011,2, 661-665

Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivoantimalarial activities

F. Marti, J. Chadwick, R. K. Amewu, H. Burrell-Saward, A. Srivastava, S. A. Ward, R. Sharma, N. Berry and P. M. O'Neill, Med. Chem. Commun., 2011, 2, 661 DOI: 10.1039/C1MD00102G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements