Issue 7, 2011
From the journal:

MedChemComm

Synthesis and biological evaluation of novel 1-aryl, 5-(phenoxy-substituted)aryl-1,4-pentadien-3-one derivatives†

Kai Yuan,a   Baoan Song,*a   Linhong Jin,a   Shuai Xu,a   Deyu Hu,a   Xiaoqing Xua  and  Song Yang*a  

* Corresponding authors

a State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China
E-mail: songbaoan22@yahoo.com

Abstract

A series of 1-aryl, 5-(phenoxy-substituted)aryl-1,4-pentadien-3-one derivatives were synthesized and evaluated for anticancer activity. Amongst the synthesized ethers, 4A and 4Y exhibited substantial antiproliferative activity with IC50 values ranging from 6.6–8.6 μmol L−1 against a variety of human cancer cell lines. Preliminarily mechanism of antitumor action of 4A by DNA Ladder, Annexin V/PI double staining and related studies indicated growth inhibition of PC3, BGC-823 and Bcap-37 cells by induction of tumor cells apoptosis.

Graphical abstract: Synthesis and biological evaluation of novel 1-aryl, 5-(phenoxy-substituted)aryl-1,4-pentadien-3-one derivatives

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Article information

DOI
https://doi.org/10.1039/C1MD00038A
Article type
Concise Article
Submitted
07 Feb 2011
Accepted
25 Mar 2011
First published
14 Apr 2011

Med. Chem. Commun., 2011,2, 585-589

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Synthesis and biological evaluation of novel 1-aryl, 5-(phenoxy-substituted)aryl-1,4-pentadien-3-one derivatives

K. Yuan, B. Song, L. Jin, S. Xu, D. Hu, X. Xu and S. Yang, Med. Chem. Commun., 2011, 2, 585 DOI: 10.1039/C1MD00038A

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