Esterprodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies†
Abstract
Novel
* Corresponding authors
a Université Lille Nord de France, Université de Lille1, Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, B.P. 90108, Villeneuve d'Ascq Cedex, France
b Laboratoire de Chimie Générale, Facultés de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine (CP 206/4), boulevard du Triomphe, Brussels, Belgium
c Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
d CIIL, Inserm U 1019, UMR CNRS 8024 Université Lille Nord de France, Institut Pasteur de Lille, 1 rue du Pr Calmette, Lille Cedex, France
e Institut de Recherche Biomédicale des Armées, Antenne de Marseille, Unité de Parasitologie, URMITE-UMR 6236, Allée du Médecin Colonel Jamot, Parc le Pharo, BP 60109, Marseille Cedex 07, France
f Structural Biology Brussels & Molecular and Cellular Interactions, VIB, Pleinlaan 2, Brussels, Belgium
g
Université Lille Nord de France, Université de Lille1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, Villeneuve d'Ascq Cédex, France
E-mail:
christophe.biot@univ-lille1.fr
Fax: +33 320436555
Tel: +33 320436941
Novel
F. Dubar, R. Wintjens, É. S. Martins-Duarte, R. C. Vommaro, W. de Souza, D. Dive, C. Pierrot, B. Pradines, A. Wohlkonig, J. Khalife and C. Biot, Med. Chem. Commun., 2011, 2, 430 DOI: 10.1039/C1MD00022E
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