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Issue 5, 2011
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Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

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Abstract

The C-fucosyl peptide dendrimer D-FD2 (CFuc-lys-pro-leu)4(Lys-phe-lys-leu)2Lys-his-leu-NH2 was prepared as the D-amino acid containing stereoisomer of the Pseudomonas aeruginosa biofilm inhibitor FD2. D-FD2 showed lower affinity for the fucose specific lectin LecB, was also active as a biofilm inhibitor and in addition showed high stability towards proteolysis with pure proteases and in human serum.

Graphical abstract: Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

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Supplementary files

Article information


Submitted
22 Dec 2010
Accepted
14 Feb 2011
First published
10 Mar 2011

Med. Chem. Commun., 2011,2, 418-420
Article type
Concise Article

Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

E. M. V. Johansson, R. U. Kadam, G. Rispoli, S. A. Crusz, K. Bartels, S. P. Diggle, M. Cámara, P. Williams, K. Jaeger, T. Darbre and J. Reymond, Med. Chem. Commun., 2011, 2, 418
DOI: 10.1039/C0MD00270D

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