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Issue 3, 2011
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Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold

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Abstract

A novel series of nNOS inhibitors with an amidinothiophene-hydroxypiperidine scaffold was designed based on X-ray structures and in-silico models. Three classes of inhibitors with this scaffold were synthesized and tested for their nNOS activity and eNOS selectivity. Compounds with a linear aliphatic amine linker demonstrated a superior property over those with a sulfonamide or an amide-like linker.

Graphical abstract: Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold

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Publication details

The article was received on 10 Dec 2010, accepted on 05 Jan 2011 and first published on 26 Jan 2011


Article type: Concise Article
DOI: 10.1039/C0MD00255K
Med. Chem. Commun., 2011,2, 201-205

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    Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold

    G. Liang, K. Neuenschwander, X. Chen, L. Wei, R. Munson, G. Francisco, A. Scotese, G. Shutske, M. Black, S. Sarhan, J. Jiang, I. Morize and R. J. Vaz, Med. Chem. Commun., 2011, 2, 201
    DOI: 10.1039/C0MD00255K

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