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Issue 12, 2011
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Hierarchical mesoporous bio-polymer/silica composites co-templated by trimethyl chitosan and a surfactant for controlled drug delivery

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Abstract

In this communication, we report the facile synthesis of hierarchical mesoporous bio-polymer/silica composite materials with bimodal mesopores using a dual-template of the cationic N,N,N-trimethyl chitosan (TMCs) and the anionic sodium dodecyl sulfate (SDS) via one-step synthetic strategy. Tetraethoxysilane (TEOS) was used as a silica source. The nitrogen adsorption/desorption measurements and transmission electron microscopy analysis showed the hierarchical structure of the mesoporous bio-polymer/silica composites with bimodal mesopores having an average pore size of 5–7 nm with the visible voids between the silica nanoparticles, which allow the mesoporous bio-polymer/silica composites to encapsulate a large number of guest drug molecules, Ibuprofen (IBU) or 5-fluorouracil (5-FU), due to their high surface area and pore volume. In addition, the mesoporous chitosansilica composites also had a long term biocompatibility for the target release of the drug molecules to the CEM cells, MCF cells, etc. as well as a pH sensitive controlled release behavior of the drug molecules.

Graphical abstract: Hierarchical mesoporous bio-polymer/silica composites co-templated by trimethyl chitosan and a surfactant for controlled drug delivery

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Publication details

The article was received on 15 Nov 2010, accepted on 21 Jul 2011 and first published on 23 Aug 2011


Article type: Concise Article
DOI: 10.1039/C0MD00222D
Med. Chem. Commun., 2011,2, 1162-1166

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    Hierarchical mesoporous bio-polymer/silica composites co-templated by trimethyl chitosan and a surfactant for controlled drug delivery

    V. K. Rana, S. S. Park, S. Parambadath, M. J. Kim, S. Kim, S. Mishra, R. P. Singh and C. Ha, Med. Chem. Commun., 2011, 2, 1162
    DOI: 10.1039/C0MD00222D

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