Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays†
Abstract
The
* Corresponding authors
a Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Italy
b Berlin Institute for Medical System Biology at the Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, Berlin, Germany
c Department of Chemical Biology, University of Padua, Viale G. Colombo 3, Padova, Italy
d Institute of Neuroscience (CNR), c/o Department of Chemical Biology, University of Padua, Viale G. Colombo 3, Padova, Italy
e Department of Chemistry, University of Sassari, Via Vienna 2, Sassari, Italy
f Mass Spectrometry Centre (CISM), University of Florence, Via U. Schiff 6, Sesto Fiorentino, Italy
g
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
E-mail:
angela.casini@epfl.ch
Fax: +41 21 6939865
Tel: +41 21 6939860
The
C. Gabbiani, G. Mastrobuoni, F. Sorrentino, B. Dani, M. P. Rigobello, A. Bindoli, M. A. Cinellu, G. Pieraccini, L. Messori and A. Casini, Med. Chem. Commun., 2011, 2, 50 DOI: 10.1039/C0MD00181C
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