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Issue 3, 2011
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The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

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Abstract

Using evolved pyrrolysyl-tRNA synthetase–tRNAPylCUA pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

Graphical abstract: The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

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Article information


Submitted
30 Sep 2010
Accepted
16 Dec 2010
First published
14 Jan 2011

Mol. BioSyst., 2011,7, 714-717
Article type
Communication

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives

Y. Wang, W. K. Russell, Z. Wang, W. Wan, L. E. Dodd, P. Pai, D. H. Russell and W. R. Liu, Mol. BioSyst., 2011, 7, 714
DOI: 10.1039/C0MB00217H

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