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Issue 24, 2011
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Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

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Abstract

Most laboratory assays take advantage of multi-step protocols to achieve high performance, but conventional paper-based tests (e.g., lateral flow tests) are generally limited to assays that can be carried out in a single fluidic step. We have developed two-dimensional paper networks (2DPNs) that use materials from lateral flow tests but reconfigure them to enable programming of multi-step reagent delivery sequences. The 2DPN uses multiple converging fluid inlets to control the arrival time of each fluid to a detection zone or reaction zone, and it requires a method to disconnect each fluid source in a corresponding timed sequence. Here, we present a method that allows programmed disconnection of fluid sources required for multi-step delivery. A 2DPN with legs of different lengths is inserted into a shared buffer well, and the dropping fluid surface disconnects each leg at in a programmable sequence. This approach could enable multi-step laboratory assays to be converted into simple point-of-care devices that have high performance yet remain easy to use.

Graphical abstract: Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

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Supplementary files

Article information


Submitted
13 Aug 2011
Accepted
12 Oct 2011
First published
28 Oct 2011

Lab Chip, 2011,11, 4274-4278
Article type
Technical Note

Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

B. R. Lutz, P. Trinh, C. Ball, E. Fu and P. Yager, Lab Chip, 2011, 11, 4274
DOI: 10.1039/C1LC20758J

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