Jump to main content
Jump to site search

Issue 20, 2011
Previous Article Next Article

Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics

Author affiliations

Abstract

Exposure of a negative photoresist-coated glass slide with diffused light from the backside through a mask with disconnected features provides multi-level rounded channels with narrow orifices in one exposure. Using these structures, we construct microfluidic systems capable of creating aqueous two-phase system droplets where one aqueous phase forms droplets and the other aqueous phase forms the surrounding matrix. Unlike water-in-oil droplet systems, aqueous two-phase systems can have very low interfacial tensions that prevent spontaneous droplet formation. The multi-level channels fabricated by backside lithography satisfy two conflicting needs: (i) the requirement to have narrowed channels for efficient valve closure by channel deformation and (ii) the need to have wide channels to reduce the flow velocity, thus reducing the capillary number and enhancing droplet formation.

Graphical abstract: Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics

Back to tab navigation

Supplementary files

Article information


Submitted
27 Jun 2011
Accepted
10 Aug 2011
First published
05 Sep 2011

Lab Chip, 2011,11, 3551-3554
Article type
Technical Note

Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics

D. Lai, J. P. Frampton, H. Sriram and S. Takayama, Lab Chip, 2011, 11, 3551
DOI: 10.1039/C1LC20560A

Social activity

Search articles by author

Spotlight

Advertisements